Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. Healthline Media does not provide medical advice, diagnosis, or treatment. Milk thistle may not be safe for everyone. Anticancer Drugs. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. OCD symptoms usually revolve around irrational fears, repeated thoughts, and compulsions. The silymarin extracted from milk thistle is known to have antioxidant, antiviral and anti-inflammatory properties (2, 3, 4). The data is very limited, but one randomized controlled study found that mothers taking 420 mg of silymarin for 63 days produced 64% more milk than those taking a placebo (37). Milk Thistle: Generic, Uses, Side Effects, Dosages - RxList The Gale Encyclopedia of Alternative Medicine, second edition, 2004. The active ingredients in milk thistle are a group of plant compounds collectively known as silymarin (1). edeka3 Brain Fog (anxiety, depression, ADHD), lots of medications. I think milk thistle is often used in combo with NAC to enhance it's beneficial effects. 5th ed. Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. PMC Multiple Myeloma vs. Leukemia: What Are the Differences? It usually develops slowly over a number of years and causes weak and fragile bones that break easily, even after minor falls. include protected health information. Milk thistle is often promoted for its liver-protecting effects. Abstract Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Now, one substance that we know can inhibit 5-alpha reductase, although it does it pretty weakly, is saw palmetto [200-500mg/Day, 2-3 . 2023 Jan 14;19:133-151. doi: 10.2147/NDT.S376380. However, there are currently no human studies, so its effectiveness remains unclear. People with diabetes should use caution. While the cost of most OCD medications currently available on the market is actually quite reasonable, the common side effects that occur are definitely not. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Summary Milk thistle may increase breast milk production in women who are lactating, though very little research has been done to confirm its effects. Adv Ther. *These statements have not been evaluated by the Food and Drug Administration. Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Milk thistle may not be recommended in some situations. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. However, there are currently no human studies examining the effects of milk thistle in people with Alzheimers or other neurological conditions like dementia and Parkinsons. Milk thistle is generally considered safe when taken by mouth (1, 45). A 2010 review by researchers found that black . Amyloid plaques are sticky clusters of amyloid proteins that can build up between nerve cells as you age. Can Milk Thistle Help People With Diabetes? This is especially important if you are taking any other medications for menopause or any blood thinners, such as statins. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. [Database subscription]. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Clipboard, Search History, and several other advanced features are temporarily unavailable. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. Do not use this product without medical advice if you are breast-feeding a baby. Milk thistle has a distinctive purple flower and spiky leaves, grows to about 200 cm in height, and is found throughout the world. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in. Bookshelf Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Users are advised to seek the advice of their physician or other qualified health care provider with any questions you may have regarding a medical condition. 2020;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0206/jbcpp-2019-0206.xml. Learn. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Digestion and Depression . 1982;17:51721. Milk thistle is a safe supplement that shows potential as a complementary therapy for various conditions, including liver disease, cancer and diabetes. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Efficacy and safety of milk thistle preventive treatment of anti - LWW One study questioned the benefits of milk thistle for liver diseases. A survey conducted in the U.S. reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. How Does Cirrhosis Affect Life Expectancy? 10 Supplements You Should Be Taking After Menopause Depression and anxiety are associated with increased risk of developing AD. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. An allergic reaction is more common in people who are allergic to other plants in the Asteraceae family, such as ragweed, daisies, marigolds and chrysanthemums. One particular area of interest is in milk thistle's ability to protect and perhaps restore the liver. Biomed Pharmacother. . Website: https://pubmed.ncbi.nlm.nih.gov/. DISCUSSION: Why do I feel better with Milk Thistle? Era of Hope Meeting for the Department of Defense Breast Cancer Research Program, Atlanta, June 8-11, 2000. Its unclear what benefits, if any, it may have in the body, but its sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. Pharmacol Rev. Milk Thistle | NCCIH doi:10.1515/jbcpp-2019-0206, Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. J Diabetes Res. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. doi:10.1097/CAD.0000000000000211, Fallah M, Davoodvandi A, Nikmanzar S, et al. Herbal Remedies for OCD and Anxiety Disorders - Verywell Mind Natural Medicines Comprehensive Database: "Milk Thistle Monograph. Biomed Res Int. Neurological Disorders Milk thistle has long been used to alleviate the inflammation commonly associated with a host of neurological disorders such as dementia, Alzheimers, and Parkinsons Disease (8). In reducing oxidative stress, milk thistle is believed to be neuroprotective by helping prevent decline in brain function. About curcumin, it isn't usually a problem but if you're on IMAOs you may like to read a bit before taking high doses. a history of endometriosis or uterine fibroids. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. Some studies also show milk thistle may help people whose liver is damaged by industrial toxins, such as toluene and xylene. Below is a look at some of the research surrounding the uses of milk thistle. Milk thistle may be useful in treating liver disease, cancer, and diabetes. Milk thistle (Silybum marianum) is a plant traditionally used as a liver tonic. Accessed Oct. 30, 2020. Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. 2014;97 Suppl 11:S31-S40. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Silibinin significantly attenuated anxiety/depression-like behaviors caused by A1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST). Its been suggested that the antioxidant effects of silymarin may have some anticancer effects, which could be helpful for people receiving cancer treatment (9). Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. It is not certain whether milk thistle is effective in treating any medical condition. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. There are no other food sources of this herb. #1: Milk thistle detoxifies the liver. Anxiety; Autophagy; BDNF; Depression; Silibinin. Milk thistle is sold as an oral capsule, tablet and liquid extract. Side effects. By Brittany Lubeck, RD (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Botanicals and their bioactive phytochemicals for women's health, Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review, Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. Hepatology. 1. https://iocdf.org/about-ocd/ocd-treatment/meds/, International OCD Foundation, Medications for OCD, By By Michael Jenike, MD, Retrieved May 5, 2019, 2. https://theoakstreatment.com/blog/ocd-facts-and-statistics/, The Oaks Treatment, OCD Facts and Statistics, Published June 18, 2018, Retrieved May 5, 2019, 3. https://www.psycom.net/ocd-medication-guide/, Psycom.net, OCD Medication Guide, By Kathleen Smith, PhD, Last Updated September 21, 2018, 4. https://www.ncbi.nlm.nih.gov/pubmed/20564545, Phtotherapy Research, Milk thistle in liver diseases: past, present, future, Published October 24, 2010, Retrieved May 5, 2019, 5. https://www.drugs.com/npp/milk-thistle.html, Drugs.com, Milk Thistle, Last updated on Mar 1, 2019, Retrieved May 5, 2019, 6. https://www.verywellhealth.com/the-benefits-of-milk-thistle-88325, VeryWellHealth.com, The Benefits of Milk Thistle, By Kathee Wong, Updated March 08, 2019, Retrieved May 5, 2019, 7. https://linkinghub.elsevier.com/retrieve/pii/S0944711315000227, Phytomedicine, Effects of Silybum marianum (L.) Gaertn. Malaria. Accessed Oct. 30, 2020. Abstract Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. Not available for orders containing UltraNourish. Int J Mol Sci. Thus, more studies are needed to determine what dose and length of treatment are needed for specific liver conditions (2, 11, 12). Side effects are always possible when taking supplements. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Silymarin as supportive treatment in liver diseases: a narrative review. 2016;5147468. doi:10.1155/2016/5147468. Silybum marianum (milk thistle). If you or anyone you know is living with obsessive compulsive disorder (OCD), proclaiming the symptoms of this mood disorder as debilitating is a vast understatement. Luckily, more and more experts are turning to natural remedies to answer that question and circumvent the litany of side effects. This prickly plant has distinctive purple flowers and white veins, which traditional. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. There's limited evidence, though, for the role of milk thistle in bone health. Seeff, L.; Curto, T.; Szabo, G. et al. information is beneficial, we may combine your email and website usage information with People have traditionally used milk thistle for problems with the liver and gallbladder . Osteoporosis is a disease caused by progressive bone loss. By lowering LDL "bad" cholesterol levels, milk thistle may lower the chance of developing heart disease. To ensure quality and potency in your herbal remedies, why not grow your own? MeSH 2013 Nov;19(11):847-53. doi: 10.1111/cns.12175. This herb (also known as Silybum marianum) is native to the Mediterranean region. However, this is the only clinical study available. "It helps to clear out the toxins and nourish the organ," says Justice. Milk Thistle Benefits - Verywell Health Theres some evidence that milk thistle can treat cirrhosis and chronic hepatitis, which can be caused by alcohol abuse, autoimmune disease, or viruses. Researchers believe that silymarin reduced the oxidative stress traditionally attributed with diabetes (7). Matutino Santos P, Pereira Campos G, Nascimento C. Neuropsychiatr Dis Treat. Cathy Wong is a nutritionist and wellness expert. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. Reflux Risk and Relief View More . Over the Counter & Complementary Therapies | Parkinson's Foundation Fried, M.; Navarro, V.; Afdhal, N. et al. One reported effect of milk thistle is that it can boost breast milk production in lactating mothers. Milk thistle is often sold as an herbal supplement. Bookmark the permalink. Milk thistle (PDQ): Health Professional Version. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To provide you with the most relevant and helpful information, and understand which . Additionally, the antioxidant and anti-inflammatory properties of milk thistle may also be useful for reducing the risk of developing diabetic complications like kidney disease (43). Clin Exp Pharmacol Physiol. Milk thistle may be a useful complementary therapy to help manage type 2 diabetes.
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